RNA "Google Map" of the brain achieves nanoscale resolution

30-Jan-2021
From Technology Networks
Over the last decade the field of genomics, which enables the extraction and in-depth study of RNA molecules from any tissue, has transformed biology and medicine. Molecules derived from a tissue of a healthy individual, for example, can be compared to molecules of a diseased individual, potentially revealing the cause of disease.

Until now this powerful approach has been limited to studying molecules outside the tissue. But for the proper function of tissues, it is important to identify the location of RNA molecules inside them. In a paper published today in the journal Science, researchers from Bar-Ilan University, Harvard University and the Massachusetts Institute of Technology (MIT) reveal that they have succeeded in developing a technology that allows them, for the first time, to pinpoint millions of RNA molecules mapped inside tissues with nanoscale resolution.


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